publications.

Multiplexed genome regulation in vivo with hyper-efficient Cas12a.

​Guo LY*✉, Bian J*, Davis AE, Liu P, Kempton HR, Zhang X, Chemparathy A, Gu B, Lin X, Rane DA, Xu X, Jamiolkowski RM, Hu Y, Wang S✉, Qi LS✉. 

* Co-first authors

✉ Co-corresponding authors

Nature Cell Biology, 2022.  Link

Scalable biological signal recording in mammalian cells using Cas12a base editors.

Kempton HR, Love KS, Guo LY, Qi LS.

Nature Chemical Biology, 2022.  Link

CRISPR: Beyond Gene Editing [Review]

Guo LY, Qi LS, Wang S, Smith SJ, Leung LS, Mahajan VB.

Retina Today, 2022. Link

Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP.

Zasadzińska E, Huang J, Bailey AO, Guo LY, Lee NS, Srivastava S, Wong KA, French BT, Black BE, Foltz DR

Development Cell, 2018.  Link

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition.

​Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, & Black BE.

Nature Communications, 2017.  Link

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly.

Stankovic A, Guo LY, Mata JF, Bodor DL, Cao XJ, Bailey AO, Shabanowitz J, Hunt DF, Garcia BA, Black BE, Jansen LET.

Molecular Cell, 2017.  Link

The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

McKinley KL, Sekulic N, Guo LY, Tsinman T, Black BE, Cheeseman IM.

Molecular Cell, 2015.  Link

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.

Falk SJ*, Guo LY*, Sekulic N*, Smoak EM*, Mani T, Logsdon GA, Gupta K, Jansen LET, Van Duyne GD, Vinogradov SA, Lampson MA, Black BE.

* Co-first authors

Science, 2015.  Link

Both tails and the centromere targeting domain of CENP-A are required for centromere establishment.

Logsdon GA, Barrey EJ, Bassett EA, DeNizio JE, Guo LY, Panchenko T, Dawicki-McKenna JM, Heun P, Black BE.

Journal of Cell Biology, 2015.  Link